Check out what is mupirocin ointment used for, work function & benefits

Mupirocin comes under the group of drugs known as topical antibiotics. To treat skin diseases brought on by certain bacteria, it is given topically to the skin. There are more off-label and secondary uses for mupirocin ointment. If you are suffering from skin infections and want to know what is mupirocin ointment used for, this write-up will assist you. 

what is mupirocin ointment used for? 


1.Treatment for impetigo

Impetigo is a bacterial skin infection that is very much contagious and generally affects children. The pathogenic microorganisms, primarily Staphylococcus aureus and Streptococcus pyogenes, can be successfully removed with the mupirocin ointment. Its antibacterial effect aids in the healing and containment of impetigo lesions.


2.Nasal Carriage of Methicillin-Resistant Staphylococcus aureus (MRSA)

Mupirocin ointment can be provided to patients who have MRSA colonisation in their nasal passages. This use is especially important for halting the spread of MRSA in healthcare facilities like hospitals.


3.Catheter infections

So, what is mupirocin ointment used for? You will be surprised to know that it is also used in preventing catheter infections. People who have indwelling catheters or who are receiving dialysis run a higher risk of infection at catheter or dialysis exit sites. Regular administration of mupirocin ointment can help prevent bacterial colonisation at the catheter exit site and lower the risk of catheter-related illnesses.


4.Skin infections 

Mupirocin ointment is frequently used to treat secondary skin infections that develop as a result of small cuts, abrasions, or insect bites. It lessens the chance of acquiring more serious infections by stopping the growth of bacteria in the afflicted area and promoting wound healing.


5.Furuncles and carbuncles

Boils known as carbuncles and furuncles are agonising skin diseases brought on by microorganisms, most often Staphylococcus aureus. These diseases can be treated with mupirocin salve by bringing down bacterial colonisation, diminishing side effects, and rushing mending.

6.Dermatitis and eczema

Where secondary bacterial infections are frequent in dermatitis and eczema cases, mupirocin ointment may be helpful. It provides relief, speeds up the healing process, and aids in reducing the bacterial overgrowth in the affected skin.


7.Minor skin intervention 

Healthcare practitioners frequently advise administering mupirocin ointment to the afflicted area prior to minor surgical procedures or skin interventions to prevent infection. By lowering the possibility of bacterial infection, this preventative treatment makes recovery easier.


8.Folliculitis treatment

Folliculitis treatment is another important one to know if you are wondering what is mupirocin ointment used for. Folliculitis, an infection of the hair follicles, causes localised skin irritation and discomfort. The bacterial pathogens producing folliculitis are successfully eradicated by mupirocin ointment, which also relieves symptoms and treats the infection.


9.Treatment for Staphylococcal Skin Infections in Athletes

Staphylococcus aureus skin infections are common in athletes, especially those who play contact sports. Mupirocin ointment works well at curing these infections, allowing sportsmen to swiftly and safely resume their activities.


10.Surgical site infections 

Mupirocin ointment is often used in surgical practice as part of a preoperative prophylaxis program to reduce the incidence of surgical site infections. As it lessens the bacterial load in the nasal cavity, it is especially helpful in procedures involving the nasal passages.


Work function of mupirocin ointment 

Now that you know what is mupirocin ointment used for, let’s have a look at the work function of it. The ointment works in different steps. Those include-


1.Isoleucyl Transfer-RNA Synthetase Binding

Mupirocin binds to the bacterial enzyme isoleucyl transfer-RNA synthetase with a high affinity. It binds to the active site of the enzyme in a competitive manner, blocking the normal binding of transfer RNA and isoleucine. This interferes with the enzyme’s normal operation and hinders bacterial protein production.


2.Decreased Protein Synthesis

Mupirocin inhibits isoleucine incorporation into bacterial proteins by binding to isoleucyl transfer-RNA synthetase. This causes the bacterial cells to produce defective and non-functional proteins. Inhibiting protein synthesis ultimately interferes with crucial biological functions, making it difficult for the bacteria to survive and grow.


3.Disruption of cell wall formation 

Mupirocin obstructs the development of peptidoglycan, a fundamental part of the bacterial cell wall, which would upset the arrangement of the cell mass of the bacterium. Mupirocin compromises the strength and respectability of the bacterial cell wall by forestalling the incorporation of isoleucine into the antecedents of the cell wall. The bacterial cells become more defenceless against immune attack because of this.


Benefits of mupirocin ointment 

Besides knowing what is mupirocin ointment used for and work function, you should also know its benefits. 


1.Effective Against Gram-Positive Bacteria

Mupirocin displays solid viability against various gram-positive microscopic organisms, including methicillin-safe kinds of Staphylococcus aureus and Streptococcus pyogenes. These microorganisms are generally the reason for a few sorts of skin infections, and mupirocin’s viability against them assists patients with recuperating from their diseases.

2.Minimal side effects 

Mupirocin ointment generally has few negative effects and is well tolerated by patients. The likelihood of systemic adverse responses is decreased because it is primarily used topically, which limits the systemic absorption. People who want to find out what is mupirocin ointment used for, can be sure of the fact that the side effects won’t bother them. In case any negative effects occur, it is crucial to stop using the medication and seek medical help.


3.Minimum Development of Resistance

Mupirocin resistance is not commonly developed compared to other antibiotics. This is because of the way in which it specifically affects the bacterial enzyme isoleucyl transfer-RNA synthetase. Cross-resistance or negative effects on human protein production are limited because this enzyme is not found in human cells. To further lower the chance of resistance forming, mupirocin should only be used as directed and for the recommended amount of time.


4.Localised Application

The afflicted area is treated topically with mupirocin ointment. This localised application enables the treatment to be delivered directly and specifically to the infection location, increasing its concentration and bacterial eradication efficiency. It also reduces the possibility of systemic exposure.